![]() 2.1 Search strategy and study selectionįive electronic databases (Cochrane Library at the CENTRAL register, Ovid Embase, MEDLINE, Scopus, and Google Scholar) were searched from inception to February 2021. 11 The review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) with the ID number CRD42021228455. The meta-analysis was conducted complying with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 10 and the Meta-Analysis Of Observational Studies in Epidemiology (MOOSE) statement guidelines. The research protocol was designed a priori, defining methods for searching the literature. The aim of the present systematic review and meta-analysis was to investigate the clinical characteristics of pregnant women who died due to COVID-19. 9 Therefore, evidence concerning the impact of pregnancy as well as its co-morbidities on COVID-19–related maternal mortality is still uncertain. 3, 8 Moreover, new findings from studies conducted in low-resource countries showed an increased risk of death in obstetric patients who tested positive for SARS-CoV-2. 7 On the contrary, women of reproductive age are expected to have 60% less access to intensive care units (ICUs) than postmenopausal women. For this reason, they could be more exposed to contagion than nonpregnant women. 5, 6 However, it is ascertained that pregnant women cannot avoid mandatory examinations therefore, they cannot avoid interactions with healthcare professionals. 4 Nevertheless, it seems that pregnancies affected by COVID-19 do not develop more severe symptoms compared to the general population and an increased risk for pregnant women, compared to non-pregnant women, has not been demonstrated yet. 3 The morbidity rate of COVID-19 in pregnant women is higher than MERS, SARS, and also influenza and Ebola. ![]() The reported mortality for SARS-Cov-2 is estimated in the range of 1%–2%, less than other coronaviruses including Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS), for which the reported rate of death is estimated at about 35% and 10%, respectively. The severity of the disease ranges from asymptomatic to acute respiratory distress. ![]() 2 Specific consequences of the infection on pregnancy and neonatal outcomes are still uncertain since evidence regarding the disease is still ongoing. The clinical course of the disease frequently starts with low-grade fever, cough, anosmia, ageusia, headache, chest pain, or pneumonia. To date, the disease is still causing harmful consequences in almost every country. ConclusionĬOVID-19 with at least one co-morbidity increases risk of intensive care and mortality.ĬOVID-19 was declared a pandemic by WHO on March 11, 2020, during its 51st situation report. Overall, at least one severe co-morbidity showed a twofold increased risk of death (RR 2.26, 95% CI 1.77–2.89, I 2 = 76%). Obesity doubled the risk of death (relative risk 2.48, 95% confidence interval 1.41–4.36, I 2 = 0%). Thirteen studies with 154 deceased patients were included. The primary outcome was maternal co-morbidity. Relevant data were extracted and tabulated. Studies that compared deceased and survived pregnant women with COVID-19. Search strategyĬochrane Library, Embase, MEDLINE, Scopus, and Google Scholar were searched from inception to February 2021. ![]() To evaluate the characteristics of pregnant women who died due to COVID-19. Besides reducing the quality of obstetric care, the direct impact of COVID-19 on pregnancy and postpartum is uncertain.
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